A significant success was achieved in treatment of oncological and oncohematological diseases

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New medical technologies have been developing very quickly in the last decades. A significant success was achieved in treatment of oncological and oncohematological diseases. Development of transplantology increases chances of oncologic patients for recovery. However application of cytostatic and immune suppressing medications, ensuring functioning of transplantates, leads to severe decreasing of immunity and appearance of complications in a form of opportunistic infections. Besides, group of infections development risk includes patients suffering from acquired immune deficiency syndrome (AIDS), complications after abdominal surgical interventions, major severe burns, and premature newborns or newborns subjected to aggressive medical therapy within the first days of life (parenteral feeding and massive antibacterial therapy). Among contributive risk factors of invasive mycoses development are intake of antibiotic with a wide spectrum for more than two weeks, total intravenous nutrition, continuous artificial lung ventilation, shock, preceding mycotic infections.
Results of 8124 autopsies show that incidence of mycotic infections in clinics of Frankfurt on the Main has increased from 2.2% in 1978 to 5.3% in 2004. This increase happened mainly due to aspergillus infection, incidence of which has increased 10 times within this period of time.

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Bioplasm 9d nls analyzer-picture dependence on clinical symptoms

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To fulfill mycological examination of a phlegm and liquid from bronchi, phlegm was gathered into a sterile container after cleaning of mouth cavity (tooth brushing, gargling with soda liquor), liquid from bronchi was gathered during bronchoscopic investigation.
To carry out histological research the authors used paraffin and frozen section, colored with haematoxylin and eosin, azure II-eosin, Gram-Weigert method, PAS-response, Grocott-Gomori method.
Precipitating antibodies to Aspergillus spp. antigens were defined applying enzyme multiplied immunoassay (EMI). A part of patients was subjected to precipitation reaction.
Total IgE and specific IgE to A.fumigatus was found using methods of radioimmunosorbent test in a nuclear medicine laboratory and enzyme multiplied immunoassay in a laboratory of allergens and allergy diagnostics. Measuring of total IgE was done in kU/l (thousands of international units in a litre, 1 unit = 2.4 ng).
А.fumigatus antigen was defined by latex particle agglutination mathod by Pastorex company.

Diagnostic investigation of patients included roentgenography and computed non-linear study (bioplasm 9d nls analyzer) of a thorax. The goal of bioplasm 9d nls analyzer-graphy of a thorax was to reveal and locate changed pulmonary parenchyma, detecting of symptoms typical for mycotic affection, and revealing of bioplasm 9d nls analyzer-picture dependence on clinical symptoms and laboratory research data.

http://www.bioplasm-nls.com

New medical technologies have been developing very quickly in the last decades. A significant success was achieved in treatment of oncological and oncohematological diseases. Development of transplantology increases chances of oncologic patients for recovery. However application of cytostatic and immune suppressing medications, ensuring functioning of transplantates, leads to severe decreasing of immunity and appearance of complications in a form of opportunistic infections. Besides, group of infections development risk includes patients suffering from acquired immune deficiency syndrome (AIDS), complications after abdominal surgical interventions, major severe burns, and premature newborns or newborns subjected to aggressive medical therapy within the first days of life (parenteral feeding and massive antibacterial therapy). Among contributive risk factors of invasive mycoses development are intake of antibiotic with a wide spectrum for more than two weeks, total intravenous nutrition, continuous artificial lung ventilation, shock, preceding mycotic infections.
Results of 8124 autopsies show that incidence of mycotic infections in clinics of Frankfurt on the Main has increased from 2.2% in 1978 to 5.3% in 2004. This increase happened mainly due to aspergillus infection, incidence of which has increased 10 times within this period of time.
A peculiarity of aspergillus infection course is a variety of its clinical manifestations. Therapists single out invasive and non-invasive aspergillosis.
Invasive pulmonary aspergilliosis (IPA) is the most severe form of the disease, when dissemination of the process into other organs (CNS, parenchymatous organs of abdominal cavity) is possible. Often the first symptom of invasive mycotic infection is a fever, refractory to broad-spectrum antibiotics. Absence of a result at treatment with antibacterial preparations at clinical picture of acute pneumonia in patients with expressed immune suppression must be regarded as a possibility of IPA development. When such clinical manifestations are registered diagnostic maneuvers must be fulfilled. Speed and intensity of IPA manifestations depend on degree of immune suppression. IPA signs reveal themselves distinctly after granulocytopaenia, Sometimes IPA diagnosis may be made basing on results of a biopsy only, but a risk of haemorrhagic complications in patients with hemoblastoses may be one of barriers for biopsy.

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A risk of haemorrhagic complications in patients with hemoblastoses

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Invasive pulmonary aspergilliosis (IPA) is the most severe form of the disease, when dissemination of the process into other organs (CNS, parenchymatous organs of abdominal cavity) is possible. Often the first symptom of invasive mycotic infection is a fever, refractory to broad-spectrum antibiotics. Absence of a result at treatment with antibacterial preparations at clinical picture of acute pneumonia in patients with expressed immune suppression must be regarded as a possibility of IPA development. When such clinical manifestations are registered diagnostic maneuvers must be fulfilled. Speed and intensity of IPA manifestations depend on degree of immune suppression. IPA signs reveal themselves distinctly after granulocytopaenia, Sometimes IPA diagnosis may be made basing on results of a biopsy only, but a risk of haemorrhagic complications in patients with hemoblastoses may be one of barriers for biopsy.
bioplasm 9d nls can test human body health,and can improve human body health.