Bioplasm 9d nls with 4.9GHz high-frequency sensors

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We have examined 267 patients suffering from purulent-destructive diseases of lungs and pleura, who were treated in University College London Hospital, in 2009 – 2011. In accordance with a nosology all patients were divided into 4 groups named by the main disease: lung abscess (112 patients – 94 among them with acute abscess, 18 – with chronic one), abscessed pneumonia (79 patients), pleural empyema (54 patients) and pulmonary gangrene (22 patients). Bioplasm 9d nls-graphy data was verified by the results of surgical interventions, thoracic punctures with microbiological analysis of a punctate.

Thorax research was carried out using Bioplasm 9d nls with 4.9GHz high-frequency sensors in accordance with procedure created in the hospital. At visualization of pathological neoplasms we defined their localization, size, chromogeneity, spectral structure; applying spectral-entropic analysis (SEA) we evaluated changes of Bioplasm 9d nls-picture in dynamics. When there were pleural fluids we evaluated amount and structure of a fluid content with study of all inclusions (suspensions, threads) and condition of pleura. According to results of ultramicroscanning we judged about diagnostic value of each of mentioned criteria.

At the initial stage Bioplasm 9d nls-study of thorax was carried out after roentgenography with following comparison of results. Further on both diagnostic methods were applied simultaneously, but frequently Bioplasm 9d nls-study preceded roentgenography or replaced some part of it.

Bioplasm machine-graphy is more informative method in diagnostics

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1. Bioplasm machine-graphy is more informative method in diagnostics of invasive pulmonary mycoses in comparison with roentgenography. Its sensitivity is 86%, specificity – 75% and diagnostic accuracy – 80% (67.2-90.3) (p < 0.05).

2. X-ray pattern depends on duration of the process at IPA. In the beginning of the process (1st – 3rd day) the most frequently revealed sign is nidal and interstitial changes of lungs (75%). 4th – 7th days are characterized by prevalence of roundish induration of pulmonary tissue (75%), halo symptom is revealed (40%). After 8th day nidal and interstitial changes are revealed less frequently, air crescent symptom may be registered (9%).

Bioplasm nls software-semiotica of IPA

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Bioplasm nls software-semiotica of IPA included nidal and interstitial hyperchromogenic changes, revealed most frequently at the early stages of the disease (1st – 4th day since the moment of clinical manifestations).

On 5th – 7th day we mainly registered foci and areas of alveolar infiltration, which evidenced progressing of the process. We should note subpleural localization of nidal and interstitial changes mainly, and revealed by Bioplasm nls software-study connection of nidi and infiltration foci with vessels.

During the later period, starting from the 8th day since clinical manifestations, changes were polymorphous: we could see isochromogenic nidi, foci and infiltration areas, in rare cases – interstitial changes of pulmonary tissue. Only during the third period of IPA we registered air crescent symptom. Revealing of this symptom was a positive sign and it evidenced resolution of pathological changes.

bioplasm 9d nls analyzer-study

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The earliest signs of IPA were nidal and interstitial hyperchromogenic changes of tissues, revealed by bioplasm 9d nls analyzer-study in 75% and 67% of cases correspondingly. Roentgenography turned out to be less informative during the initial stage. Frequency of nidal and interstitial changes revealing according to roentgenography data was statistically reliably lesser – 19% and 42% correspondingly. Foci of alveolar infiltration were revealed in a significantly lesser percentage of cases according to both methods.

Nidal changes of pulmonary tissue during the second period of time (4th – 8th day) were revealed less frequently than during the first period of time. Frequency of interstitial changes areas revealing was also lesser. Foci had different shapes, more often roundish, homogeneous structure, were of subpleural location and had a connection with vessels.

Patients IPA was diagnosed with spectral-entropic analysis

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Revealing of A.fumigatus antigen in blood was carried out in all patients. A positive result was registered in 82% of cases. Cultural investigation of a phlegm and bronchoalveolar lavage was fulfilled in 69%, growth of A.fumigatus was registered in 24% and 40% correspondingly. At microscopic evaluation of a phlegm and bronchial liquid mycelium was found in 12% and 20% of cases correspondingly.

In 98.6% of patients IPA was diagnosed with spectral-entropic analysis. In affection nidi a high spectral similarity to “Aspergillus fumigatus” etalon (D<0.425) was found. At the early stages of IPA development high body temperature, more than 38, refractory to antibiotics, was registered in 54 (98%) cases, couching – in 34 (62%), pneumorrhagia – in 13 (24%). 13 (34%) patients complained about pain in thoracic region. Dissemination of the process, revealed by SEA, was registered in 3 (5%) patients, at the same time in all of them cerebral affection was diagnosed. During the study 14 (26%) patients died. In one case we registered self-recovery of the patient, in which IPA developed against the background of normal immunity.

Bioplasm 9D NLS can test human body health,and improve human body health.

Bioplasm machine-graphy of thorax organs

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During the research we used Bioplasm machine-ultramicroscanning mode with spectral-entropic analysis (SEA), allowing to evaluate spectral similarity of affected lung tissues to “Aspergillus fumigatus” etalon. During the initial fulfillment of Bioplasm machine-graphy of thorax organs, the examination was dome in three-dimensional mode mainly. Differing from two-dimensional scanning it allowed to exclude a possibility of small pathological lesions (nidi, cavities, bronchiectasis, etc.) missing, and to increase a resolution along longitudinal axis of scanning in order to check lateral structures, located perpendicularly or at an angle to Bioplasm machine-gram plane.

Computed non-linear study-Bioplasm 9d nls analyzer

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Diagnostic investigation of patients included roentgenography and computed non-linear study (Bioplasm 9d nls analyzer
) of a thorax. The goal of Bioplasm 9d nls analyzer-graphy of a thorax was to reveal and locate changed pulmonary parenchyma, detecting of symptoms typical for mycotic affection, and revealing of Bioplasm 9d nls analyzer-picture dependence on clinical symptoms and laboratory research data.
Thorax investigation was carried out using a device manufactured by Siemens Company (Germany) in two projections (frontal and lateral), supported by tomograms. Bioplasm 9d nls analyzer-graphy was carried out using “Metatron”-4025 system (IPP, Russia) equipped with high-frequency generator of 4.9 GHz, unit of continuous spiral scanning and professional software “Metapathia GR Clinical”, which allowed to carry out three-dimensional visualization of lungs.

Clinical methods of investigations

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Clinical methods of investigations included examination by a therapist, clinical and biochemical blood tests, fiber-optic bronchoscopy, study of external respiration function. Microbiological study was carried out in accordance with standard practice. To reveal supersensitiveness of an organism to possible allergens, the researchers applied a method of skin testing and revealing of specific IgE in blood serum. Allergological testing was carried out in allergology room of mycology department.

A peculiarity of aspergillus infection course

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Results of 8124 autopsies show that incidence of mycotic infections in clinics of Frankfurt on the Main has increased from 2.2% in 1978 to 5.3% in 2004. This increase happened mainly due to aspergillus infection, incidence of which has increased 10 times within this period of time.
A peculiarity of aspergillus infection course is a variety of its clinical manifestations. Therapists single out invasive and non-invasive aspergillosis.

Bioplasm machine can  test human body health,also can improve human body health.

Bioplasm machine is the most convenient

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Bioplasm machine  is the most convenient, sensitive and comparatively affordable method of patients with early rheumatoid arthritis check-up, which can be used to predict various outcomes of joints incompetence and to monitor efficiency of applied therapy, in particular, with new “biolopgical agents”.

The main symptoms revealed at Bioplasm machine-study of bones and the most inportant in early diagnostics of RA are destruction of bone tissue (erosions, cysts), ostitis and synovitis (tendinitis).

Tendinous synovitis intensity-Bioplasm nls

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Until today the only approach to evaluation of tendinitis/tendinous synovitis intensity is still not defined. According to our data tendinitis at Bioplasm nls-ultramicroscanning is shown as hyperchromogenic region in areas surrounding tendons of flexor and extensor muscles and evaluated at 5-6 points at Fleindler’s scalre. Development of tendinitis is an adverse factor for prognosis of hand joints functional condition and risk factor for development of joints destructive affection. That is why we believe necessary to recommend to carry out this evaluation in addition to standard method according to OMERACT–RAMRIS.