Bioplasm nls diagnosis pancreatitis

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According to this classification there are following types of pancreatitis:
1. Acute pancreatitis:
a) mild (edematic);
b) severe
2. Acute congestion of a liquid (in pancreatic gland tissue and in pancreatic cellular tissue).
3. Pancreatonecrosis:
a) sterile;
b) infected.
4. Pancreatic false cyst.

5. Pancreatic abscess.

Bioplasm machine solves Acute pancreatitis

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Acute pancreatitis is one of the basic problems of modern urgent surgery which is proved by steady growth of disease and high lethality rates.
The important factors defining this circumstance are: late or error diagnosis, underestimation of condition severity of patients and, correspondingly, an inadequate choice of necessary conservative and surgical measures. Principles of surgical treatment of pancreatonecrosis patients are based on the differentiated approach to the choice of operative measures depending on development phase of disease, its clinical-morphological form, severity level of patient’s condition and disease terms. Various degree of pancreatic gland necrotic affection spread and different parts of extraperitoneal cellular tissue, and also the fact of their infection define the choices variety of surgical approaches.
One of the most difficult and problem issues is the issue of acute pancreatitis classification.

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Changing of an intestinal wall structure-Bioplasm 9d nls

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In accordance with changing of an intestinal wall structure we have chosen some degrees of its affection, each was assigned with a certain number of points:
1st degree (intact structure of an intestinal wall) – 1-2 points;
2nd degree (changes of intestinal wall structure in a form of hyperchromogenic inclusions in a mucous layer) – 3 points;
3rd degree (changes of intestinal wall structure in a form hyperchromogenic inclusions in mucous and submucous layers, longitudinal defects in submucous layer or total affection of a mucous layer) – 4 points;
4th degree (changes of intestinal wall structure in a form hyperchromogenic inclusions in mucous and submucous layers, defects in submucous layer and total affection of a mucous layer, alternating with affection of other layers of an intestinal wall) – 5 points;
5th degree (total defeat of all layers) – 6 points.
For convenience of calculation endoscopic researches results were estimated in points taking into account severity of a disease.
So, remission was estimated at 1-2 points, aphthoid affection – 3 points, scarring – 4 points, ulcers – 5 points, ulcers-cracks – 6 points.

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bioplasm machine-graphy data and results of endoscopic researches

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The following data was obtained by comparison of bioplasm machine-graphy data and results of endoscopic researches.
 At endoscopic remission the structure of an intestinal wall was not changed in 93.3% of cases, affection of vessels was not detected (in 73.3% of patients) or was minor (in 26.7% of patients).

In 1 patient with remission of inflammatory process and pseudopolyposis we revealed ulcerous defects in the form of single hyperchromogenic inclusions in submucous layer, at the same time vessels affections were not expressed. It means that bioplasm machine-signs should be used only altogether for definition of an inflammatory process stage. bioplasm machine-research of this patient was carried out on next day after colonoscopy, and gas between pseudo-polyps in segmented intestine was taken for achromogenic cavities in a mucous layer. This case also says that bioplasm machine-research should be applied before colonoscopy or in 2–3 days after it.

Optimization of Bioplasm-signs calculation

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During aggravation stage we noted affection of a vascular wall, which in 64.7% of cases was severe. Changes of intestinal wall structure were revealed in 82.4% of patients, that corresponded to endoscopic stage of ulcers and ulcers-cracks. However it should be noted that during aphthoid and scarrings stages (17.6% of patients), no pathologically changed vessels were observed in the presence of affected wall.
For definition of correlation degree between Bioplasm-signs (a condition of an intestinal wall, vascularisation) and stages of endoscopic changes at Crohn’s disease we used rank correlation method of Spearman. For optimization of Bioplasm-signs calculation depending on expressiveness of the process they were assigned with a certain amount of points. Undamaged intestinal wall was marked with 1-2 points.

Bioplasm nls-graphy detected inflammatory changes

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As it seen from the Table 1, data of Bioplasm nls and other methods of research completely coincide at colitis, but at affection of twisted intestine only, it was possible to locate inflammatory process by Bioplasm nls-research in 29 of 31 (93.5%) cases. In 2 cases Bioplasm nls-graphy detected inflammatory changes not only in small intestine, but in large intestine also. The retrospective analysis of these cases has shown that they are caused by insufficient experience of an expert who worked at the initial stage of work. At affection of large and twisted intestine location of inflammatory process was established correctly in 38 of 40 (95.0%) cases. During analysis of false-negative results it was established that in one case failure has occurred because of shortening of the right parts of large intestine and a high arrangement of head of blind colon (changes in twisted intestine about 3 cm long were considered to be changes in large intestine). In other case Bioplasm nls-research was carried out on next day after colonoscopy that has complicated evaluation of intestinal wall structure. It means that Bioplasm nls-research must be carried out in 2–3 days after carrying out of other instrumental methods of diagnostics. Thus, we have proven high informativity of diagnostics of inflammatory process location.

Bioplasm machine-semiotics elaboration

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At Bioplasm machine-research of intestines we paid attention to chromogeneity of an intestinal wall, its structure, distribution of layers, extent of inflammatory process.
The basis of large intestine inflammatory diseases Bioplasm machine-semiotics elaboration was five-layer character of intestine walls.

At the first stage of work we studied Bioplasm machine-semiotics of Crohn’s disease. To carry out this objective we studied 29 postoperative macropreparations with Crohn’s disease after various operations.

Bioplasm 9d nls analyzer-full scale colonoscopy

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According to the objective we have surveyed 114 patients with Crohn’s disease of 16 – 73 years old (average age 33 years), among them 53 men and 61 woman. Crohn’s disease proceeded in form of ileitis in 31 case, ileocolitis – in 40, colitis – in 43. Due to inefficiency of conservative therapy and development of complications 61 patients were operated. Endoscopic research was applied in 93 cases, radiological – in 76. Due to severe pain syndrome, full scale colonoscopy was not possible in 12.9% of cases.
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Bioplasm nls software-diagnostics method

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To identify Crohn’s disease degree of activity a Best’s index is used. Except Best’s index there are also conditional biological markers of expressiveness of inflammatory process, such as C-reactive protein, erythrocyte sedimentation rate, number of platelets, fibrinogens, and also endoscopic and contrast methods of research. However instrumental methods of investigation have the lacks related to a risk of disease aggravation during preparation for given inspection and an irradiation. Bioplasm nls software-diagnostics method has no such flaws.

Bioplasm nls software with angiography is an informative method

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Disappearance of abscess formation sites in all patients was noted in 6 weeks after initiation of treatment, at the same time in structure of 2 sites we noted formation of small fibrous sites.
Thus, Bioplasm nls software with angiography is an informative method of prostate abscess conservative treatment monitoring an in out-patient conditions.

Bioplasm 9d nls analyzer-angiography has shown positive changes

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Dynamic observation during a small period of time has shown that tumor sites and cystic degeneration areas do not change in structure and size; abscess formation sites, in case of a positive response to therapy decrease in size, when they disappear formation of small fibrous sites in a projection of these sites is possible.

In our research within the first two weeks (10-14 days) in 9 patients we marked reduction of abscess formation sites after applied therapy, Bioplasm 9d nls analyzer-angiography has shown positive changes in a vascular wall condition in 9 patients. In 2 cases because of positive dynamics absence, a correction of antibacterial therapy was done.

Differential diagnostics of an abscess at Bioplasm 9d nls

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Differential diagnostics of an abscess at Bioplasm 9d nls is carried out with cysts and with rostate gland cancer sites. Simple cysts and cystic degeneration of prostate gland are sonographically similar to developed prostate abscess, but differ in location (more often: a single central location at congenital cysts or location in the central part against the background of adenomatously changed parenchyma). It is difficult to differentiate an abscess and cancer of prostate gland. Distinctive criteria at Bioplasm 9d nls are considered to be: location – an abscess is more often located in a transitive zone of a gland, but cancer – in peripheral; size – more often an abscess is larger than a tumor, at an abscess – presence of changes in structure and size at dynamic treatment. In diagnostically difficult cases SEA of prostate gland is recommended. In our opinion, location and size are not the exact diagnostic criteria: in the presence of large tumors a cystic component may be present in their structure, which is a site of disintegration. In 8 patients of our research, abscess formation sites were located in a peripheral zone, and the average size of them was small – comparable with a tumor site.

Bioplasm with NLS-ultramicroangiography

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In 2 patients due to absence of positive dynamics according to results of SEA at Bioplasm with NLS-ultramicroangiography, correction of antibacterial therapy was fulfilled. At the control researches, carried out within 3-5 weeks during the course of treatment, positive dynamics in the form of normalisation of SEA results was detected in all patients. There was a gradual decrease of chromogeneity of the affected areas. The quantity of hyperchromogenic areas has decreased – to 5 (in 2 patients multiple abscess of the gland were diagnosed), their chromogeneity was lower in comparison with the previous researches. In patients with remaining abscess formation areas, complete disappearance of such areas happened in 6 weeks from the start of treatment. Research in a Bioplasm-angiography mode has shown in most cases gradual restoration of a vascular channel in a projection hyperchromogenic zones after treatment.

Bioplasm machine have more features and databases

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On the basis of digital rectal examination prostate abscess was suspected in 4 patients, we detected: enlargement and morbidity of prostate glands, fluctuation symptom was marked. In other patients the gland was enlarged and was painful, in these cases a preliminary diagnosis was made: an aggravation of a chronic prostatitis.
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Bioplasm 9d nls analyzer with NLS-angiography possibilities

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Three-dimensional Bioplasm 9d nls analyzer has proved itself as simple, noninvasive and highly informative diagnostics method, thanks to absence of beam loading. The issue of Bioplasm 9d nls analyzer  application in monitoring of conservative treatment of prostate abscess is studied insufficiently.
The purpose of this work is studying of Bioplasm 9d nls analyzer with NLS-angiography possibilities in monitoring of conservative treatment of prostate abscess.

Introduction of three-dimensional reconstruction at Bioplasm nls software

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Introduction of three-dimensional reconstruction at Bioplasm nls software, especially at application of high-frequency devices of Metatron class manufactured by the IPP, can give morphological evaluation of gastrointestinal tract wall condition.
Bioplasm nls software has prospects for allpication not only in major regional centers, but at early stages of medical assistance as well. Appearance of new equipment will stimulate and extend areas of Bioplasm nls software application. The evidence of this is a breakthrough made by IPP (Institute of Practical Psychophysics) in 2008. For the first time a system for non-linear diagnostics Bioplasm nls software capable of creating of three-dimensional reconstruction in real-time mode, was introduced in the market.

linical application of bioplasm machine is being extended

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We must emphasize that area of clinical application of bioplasm machine is being extended, because the method provides anatomical reconstruction of researched area (organ, structure), acquiring of most accurate results at evaluation of organ’s condition, analysis of ultrathin crosscuts, visualization of which is impossible at routine scanning. The information saved entirely, so it is possible to reconstruct it many times without any time limitations and in absence of a patient (patient feels no discomfort and inconvenience).

Bioplasm nls at evaluation of esophagus cancer

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Bioplasm nls made technically possible application of NLS-graphy in diagnostics of esophagus affections, extending possibilities of the method in identification of a cancer stage. 3D reconstruction contributes greatly into interpretation and quantitative analysis of a situation requiring introduction of a stent at esophagus cancer. J.Lin and D. Goldberg in a preliminary study have demonstrated a possibility of 3D reconstruction of data acquired by application of NLS-ultramicroscanning; at the same time Bioplasm nls-ultramicroscanning turned out to be more precise, than spiral CT at evaluation of esophagus cancer.

Bioplasm nls-graphy of a stomach with SEA allowed us to diagnose malignant ulcer in greater curvature of the stomach and prove involvement of regional lymph nodes.

Bioplasm application for studying of gall bladder walls condition and cholesterosis diagnostics

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 M. Sackman et al., have noted advisability of Bioplasm application for studying of gall bladder walls condition and cholesterosis diagnostics.
The authors believe that Bioplasm is a promising method for revealing of pathognomonic changes of biliary three at primary sclerosing cholangitis.

In general we must emphasize that Bioplasm completely reproduces anatomic and topographic interrelations of common hepatic duct and gall bladder, portal vein, hepatic artery and inferior vena cava.

Bioplasm 9d nls get accurate evaluation of hepatic vessels

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A special advantage is a possibility to get accurate evaluation of hepatic vessels, including tumorous ones (character of tumor vascularisation is a criterion of its growth and invasiveness, that is why such information may be decisive). Alternative CT method, allowing to get high-quality image of vascular structures without adverse side effects, is Bioplasm 9d nls-angiography. Application of SEA and Bioplasm 9d nls-ultramicroscanning of tumors presupposes promising results, but until now this question is still unanswered.
According to G. Eamat and M. El Raziky, Bioplasm 9d nls study renders invaluable help in diagnostics of chronic liver diseases in patients with ascites due to venoocclusive diseases, when obliteration of hepatic vein and minimal irregular blood flow are registered.

Bioplasm machine-graphy has great prospects

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In certain clinical situations awareness of liver condition is crucial. It is known that both own and transplanted liver tissue can regenerate, that is why visual methods gradually becoming a part of this process monitoring. Although today MRI and volumetric CT are used in this case more frequently, Bioplasm machine-graphy has great prospects, allowing to replace in the future these very expensive, complex and radiation related (CT) methods. It is very advisable, because in this case a clinician could check-up patient after, for example, liver transplantation many times.

The advantages of Bioplasm nls

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The advantages of Bioplasm nls, setting it apart from CR and MRI, are absence of ionizing radiation, safety, non-invasiveness and relatively low price. The greatest advantage of Bioplasm nls is a possibility to get ultrathin sections which are invisible at routine scanning and in precise evaluation of affected nidus condition with use of specialized programs for 3D scanning: Deep Vision, Fast Vision and ultramicroscanning with a possibility of spectral-entropic analysis (SEA) applying. Besides this method allows to manipulate acquired data, i.e. transform, rotate, zoom in and out of structures, recreating true anatomy of organs in direct projection. However today there is still no decisive answer to what role this method plays in diagnostics and what additional to 2D information it can provide?
Bioplasm nls-graphy has found its place in diagnostics of digestive organs diseases also.

Bioplasm is efficient in evaluation of lymph nodes changes in dynamics

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Extracapsular growth of metastases in lymph nodes often leads to merging of several affected lymph nodes into a conglomeration and involvement of surrounding tissues into tumorous process. Involvement of adjoining organs into a tumorous conglomeration must be identified by SEA of their morphological structure.
According to our data Bioplasm is efficient in evaluation of lymph nodes changes in dynamics.

Bioplasm nls software download

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At malignant processes in lymph nodes, central achromogenic area is visualized most frequently, which corresponds to diffuse or total replacement of central areas by necrotic tumorous tissue. In certain cases at metastatic affection of a central part of a lymph node only, it may look unchanged, because an imitation of healthy lymphoid tissue happens (it is often detected at well differentiated squamous cell cancer and other types of cancer, which are accompanied by coagulation necrosis in case of ischemic degeneration). Sometimes a lymph node may be represented as totally achromogenic formation. Although the latter is true for fatty infiltration, in these cases tumorous genesis of changes cannot be excluded completely. In this case only SEA will help to set a diagnosis.
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who needs bioplasm nls software

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Responsive changes, developing as a response to various pathological processes in an organism (inflammatory process, vaccination, etc.) are accompanied by affection of a lymph node, change of its capsule, damage of cortical and paracortical areas, which leads to increasing of chromogeneity; in a lymph node there can be single achromogenic “cystic” structures; abscess formation may be revealed later. It must be taken into account that changes in lymph nodes located near a tumor, may be manifested by non-specific reaction of inflammatory character.
Hyperplastic lymph nodes are most frequently of oval shape, with hyperchromogenic structure, thin slightly chromogenic frame, occupying about a third of a node. Hyperchromogenic nodes, with sometimes hypochromogenic center, occupying less than 2/3 of a node, may be both hyperplastic and metastatic-changed.

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Bioplasm 9d nls analyzer have a role in normal state cortical substance

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In normal state cortical substance is represented by slightly chromogenic (almost achromogenic – 1-2 points at Fleindler’s scale) homogeneous frame. Central parts (trabecules, parachylarious thickening, fatty inclusions, partially – medullary substance) are represented by hypochromogenic structure (2-3 points), portal – by homogeneous hypochromogenic structure of irregular (triangular) shape.

Structure of lymph nodes changes depending on their location. So, at analysis of structure of cervical lymph nodes located close to an organ, we see that the closes to an organ lymph nodes (non-permanent) are of smaller size, have roundish or spindled shape, and lesser presence of cortical substance. In lymph nodes located far from an organ cortical substance is developed better.

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Bioplasm 9d nls data

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Size of lymph nodes depends on age of a studied person, peculiarities of his physique, etc. In clinically healthy people lymph nodes up to 3.5 cm may be found. There is a difference in size and shape of lymph nodes of various regional groups and lymph nodes located in various areas of one and the same person.
Shape of lymph nodes generally depends on their topographoanatomical relations with surrounding organs, usually it is slightly oblong and flattened, a little prominent on the one side and minor pit on the other, resembling a bean. Sometimes shape of a lymph node may be roundish. In senile aged patients tape-like shapes of lymph nodes can be found, which may be regarded as a result of lesser nodes merging. In areas limited by fascias (for example in occipital region), nodes are more long than those located in loose tissue (for example, axillary).

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