Bioplasm-graphy has detected signs of expiratory air trap in amounts

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In 17 patients Bioplasm-graphy has detected signs of expiratory air trap in amounts from individual lobes to segments. In 7 patients the given symptom was combined with signs hypochromogeneity of pulmonary tissue at breath top. With the background of hypochromogenic zones we marked reduction of caliber of pulmonary artery’s corresponding branches. According to some authors, given symptoms indirectly evidence obliterating bronchiolitis, at which morphologists mark growth of granulations in lumen of distal bronchias and fibrosis of their walls up to almost full obliteration of lumen. As a result, at inhale the secondary lobe is filled with air, stretched, and at exhale is not fall down. The lobe restretching is not accompanied by destruction, resolution of its structures, as at emphysema.

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COPD is related to widespread diseases of a human. In the USA the tendency to increased incidence of COPD is marked: only for last period this indicator has increased by 25% in men and by 69% in women. The next years the further growth of disease is predicted. Epidemiological data related to disease incidence and death rate often underestimates importance and prevalence of COPD, as usually it is not diagnosed before clinically manifested and relatively severe stages of the disease develop. According to the American respiratory society, only 25% of disease cases are diagnosed in due time. In the USA COPD incidence grow near 15 million persons.
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According to American Thoracic Society the pulmonary emphysema (PE) is the anatomic alteration of lungs, characterized by pathological expansion of air spaces, located distal to terminal bronchiole and accompanied by destructive changes of alveolar walls. According to this definition, the obligatory symptom of PE is not only expansion, but also destruction of respiratory parts of lungs in the absence of the manifested signs of a pneumosclerosis. The emphysema is usually classified on the basis of changes in acinus and a secondary pulmonary segment.
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Bioplasm 9d nls-guidance of puncture biopsy

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In the end we want to note that if bioplasm 9d nls  reveals lesser renal tumor it is recommended to apply bioplasm 9d nls-ultramicroscanning with tree-dimensional reconstruction of bloodstream and pelvicalyceal system. In case of severe intercurrent background in a patient with lesser renal tumor it is recommended to carry out spectral-entropic analysis with bioplasm 9d nls-guidance of puncture biopsy.

Three-dimensional bioplasm machine-study data

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The following aspects must be emphasized when tumor staging is carried out.
Prior to surgical intervention the majority of patients with lesser tumor (89.3%) was considered to belong to T3a stage of cancer. This stage was set in accordance with results of pre-operative study. Local spreading of a tumor was evaluated on the basis of three-dimensional bioplasm machine-study data mainly – is a neoplasm comes out of a kidney’s contour, this stage was considered as T3a. However following study of a preparation by morphologists, that was acquired during organ-preserving or organ-removing operation has proven that in majority of patients was not growing of a tumor into paranephric fat, but squeezing of fibrous capsule of a kidney, not affected by a neoplasm. T3a stage of cancer was confirmed in 13.1% of patients corrected.

Computed bioplasm nls-graphy

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Computed bioplasm nls-graphy was applied in accordance with standard practice. During interpretation of bioplasm nls-gramms it was possible to evaluate location and size of a neoplasm, its structure and interrelation with other organs and tissues, condition of regional lymph nodes, invasion of a tumor into renal vein and inferior vena cava. Additionally we carried out computed bioplasm nls-graphy of abdominal cavity and retroperitoneum organs.

Monitoring by needle biopsy of a kidney under bioplasm 9d nls analyzer

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The recent years were marked by introduction of three-dimensional (3D) computed bioplasm 9d nls analyzer
-graphy, in addition to common two-dimensional study. Computed modeling of spatial relations of various renal structures is carried out in by ultramicroscanning with spectral-entropic analysis (SEA) with three-dimensional reconstruction that allows to specify location of a neoplasm in relation to renal vessels and calices-pelvis system in various projections, to identify morphological structure of neoplasms by spectral similarity to etalon processes. Three-dimensional bioplasm 9d nls analyzer-graphy allows to detect space-occupying mass in more than 95% of patients, to identify nature of an illness almost in 90% and to identify cancer stage in 80-85% of patients. Extensive diagnostic possibilities of mentioned methods were the reason to reconsider the importance of bioplasm 9d nls analyzer-graphy for patients suffering from renal tumor. Supporters of this point of view emphasize lesser financial expenses because of decreasing of both examination time and time of patient’s stay in hospital before surgical intervention. When a tumor is revealed by common two-dimensional examination, three-dimensional computed bioplasm 9d nls analyzer
-ultramicroangiography is applied as the next step. The advantage is given to ultramicroangiography with three-dimensional reconstruction because of a possibility to get an image of vasculature by non-invasive method. If there is a suspicion for renal cancer growing into renal vein or inferior vena cava, bioplasm 9d nls analyzer
- ultramicroangiography is a method of choice as well. If character of a neoplasm is unknown, spectral-entropic analysis with following monitoring by needle biopsy of a kidney under bioplasm 9d nls analyzer
-guidance is applied. Morphological study of tumorous tissue and identification of tumorous cells differentiation stage using spectral-entropic analysis prior to surgical intervention is one of the criteria for choosing of organ-removing or organ-preserving surgery. Results of SEA were confirmed by needle biopsy findings in majority of cases (97.3%).

USe Bioplasm 9d nls methods at research of the whole body

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However used Bioplasm 9d nls methods at research of the whole body allowed revealing some features which must be considered for an adequate assessment of changes. In such a manner false-positive results were marked in 2 patients at Bioplasm 9d nls-images. Concentration of liquids in pleural cavity, and also ovarian cysts were wrongly interpreted.
Bioplasm 9d nls  allows visualization of tissues with the initial, pre-nosological changes of tissue functioning. This fact exactly is the big advantage of this method, as well as during NLS: anatomic changes are not estimated but functional changes in tissues are analyzed.

Detection accuracy of pathological foci at Bioplasm machine research

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In 3 central lung cancer patients the received data of Bioplasm machine with spectral-entropic analysis provided precise detection of space-occupying lesion. The following factor drew attention: detection accuracy of pathological foci at Bioplasm machine research, as a rule, exceeded the values received at PET procedure. Important advantage of Bioplasm machine method is the absence of a signal from heart which may “conceal” tumoral formations at PET.

Received axial Bioplasm nls-images of body

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Received axial Bioplasm nls-images of body were processed on workstation with the use of multiplanar reconstruction algorithm, notably that color linear 6-point Fleindler’s scale was used for assessment of structures chromogeneity. 3D-model visually similar with received model at three-dimensional CT-research was rendered as a result. The assessment of received Bioplasm nls was based on the analysis of localization and quantity of chromogeneity sites with high values which corresponded to the greatest tissue damage values. Bioplasm nls-ultramicroscanning with spectral-entropic analysis was performed in all patients. Materials for carrying out of spectral-entropic analysis allowed assessment of specific expansive process according to the value of spectral similarity to pathologically altered tissues. In majority of patients the results of spectral-entropic analysis were histologically confirmed. In 90.3 % of cases the full confirmation of spectral-entropic analysis results by the data of histopathological examination was registered.

Received axial Bioplasm nls-images of body

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Received axial Bioplasm nls-images of body were processed on workstation with the use of multiplanar reconstruction algorithm, notably that color linear 6-point Fleindler’s scale was used for assessment of structures chromogeneity. 3D-model visually similar with received model at three-dimensional CT-research was rendered as a result. The assessment of received Bioplasm nls was based on the analysis of localization and quantity of chromogeneity sites with high values which corresponded to the greatest tissue damage values. Bioplasm nls-ultramicroscanning with spectral-entropic analysis was performed in all patients. Materials for carrying out of spectral-entropic analysis allowed assessment of specific expansive process according to the value of spectral similarity to pathologically altered tissues. In majority of patients the results of spectral-entropic analysis were histologically confirmed. In 90.3 % of cases the full confirmation of spectral-entropic analysis results by the data of histopathological examination was registered.

Three-dimensional nonlinear scanning Bioplasm

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Three-dimensional nonlinear scanning (Bioplasm) was included into clinical practice during last years, and at the present day it is frequently used in many areas of medicine. Main advantages of new Bioplasm-NLS method, in our opinion, are: short research time (about 30 minutes) both high sensitivity and specificity.
The use of this method provides great possibility to “see” tumoral structures against the background of non-affected tissues due to their various chromogeneity.

The objective of this research is to evaluate possibilities of Bioplasm-NLS of the whole body in assessment of tumoral process spread in patients with metastatic affection of brain.

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Positron emission tomography (PET) with the use of radiopharmaceutical 18-Fluorodeoxyglucose has high specificity and sensitivity, which means this method is the main method in assessment of disease spreading in oncological patients at the moment. In case of suspicion for brain metastatic affection, positron tomography of the whole body allows to reveal the primary nidus and to estimate disease spreading in organism in general. But, despite its advantages, this method has some essential restrictions that do not allow its using as a screening research. First of all, this is highly technical character of the method, production of radiopharmaceutical, its transportation and utilization demand additional staff except for medical personnel, another important aspect is relatively high cost of research. Long time of scanning, restrictions related with accompanying diseases (diabetes) also narrow down potentialities of this method.
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Bioplasm 9d nls analyzer-ultramicroscanning with SEA

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Although at the moment the basic methods of pulmonary affections diagnostics at lymphomas are traditional radiological research and CТ, according to received data examination of new and repeatedly surveyed patients should be started with application of Bioplasm 9d nls analyzer-graphy. In the presence of pathological changes on roentgenograms and CТ, to carry out specifying diagnostics Bioplasm 9d nls analyzer with SEA must be applied, because among the methods of visualisation applied in diagnostics of pulmonary affections at lymphomas the most universal is Bioplasm 9d nls analyzer-research (according to our data), which allows to define precisely not only location of a process, its spreading, but also to specify quantitative indicators of the given process. At doubtful results of RМ it is recommended to apply Bioplasm 9d nls analyzer-ultramicroscanning with SEA, which allows to reveal activity of process and to estimate its prevalence in lungs and lymph nodes.

Bioplasm 9d nls-graphy with SEA

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Sensitivity of a radiographic method, CТ and Bioplasm 9d nls was 88.2%; 91.6% and 93.8%, specificity – 85.1%; 92.3% and 95.7%, accuracy – 86.1%; 91.1% and 96.8% correspondingly.
In case of doubtful results of radiographic method and CТ, 9 patients were administered to Bioplasm 9d nls-graphy with SEA, which in most cases allowed to specify character of pulmonary lesion of in patients with lymphomas.

Ultramicroscanning mode with SEA of lymph nodes and lungs allowed to reveal neoplastic character of changes on early stages.

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Direct spreading of lymphoma from mediastinum into lungs or chest wall is detected in 12 patients and was registered at large conglomerates of affected lymph nodes. Spreading of process from mediastinum into lungs occurs through lymphatic ducts along bronchial tubes. Also tumor can grow from anterior and posterior mediastinum to extrapleural soft tissues of a chest wall and pericardium.

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Bioplasm nls-graphy may be related to both methods of screening diagnostics

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Bioplasm nls-graphy may be related to both methods of screening diagnostics, and to specifying diagnostics – with use of Bioplasm nls-ultramicroscanning and spectral-entropic analysis (SEA) for resolution of questionable matters of lungs diagnostics. SEA allows to identify a morphological pertain of pulmonary tumoral formations by their spectral similarity to etalon processes, to evaluate metastatic affection of lymph nodes, to detect presence and character of genetic aberrations in tumoral subclones that will define, finally, amount of surgical intervention.

Processing of the received data included a visual estimation of patient’s “whole body” image and affection areas, and also SEA of morphological substrata in the affection nidi study results.

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According to Ann Arbor classification there are two forms of lungs affection: spreading from hilum to one lobe of a lung (designated by a letter E) and hematogenic spreading into lungs (stage IV).
In diagnostics of various malignant lymphomas medics apply both traditional radiological studies, which allow to reveal enlarged intrachest lymph nodes, changes of a pulmonary tissue and pleura, and modern highly technological and more informative methods of research, such as computer tomography (CT)and computer nonlinear diagnostics (Bioplasm) which allow to evaluate prevalence of a pathological process precisely. Data obtained from various researches gives the chance to diagnose, select the most effective treatment in due time that can promote increase of duration and quality of life.

The purpose of the present research is studying of lungs affections peculiarities, first of all by means of CT and Bioplasm, in patients suffering from Hodgkin lymphoma and non-Hodgkin lymphomas with drawing up of optimum algorithm of patients check-up.

Bioplasm nls software is useful for MALT-lymphomas weaken

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Lungs affections at Hodgkin disease are often accompanied by intrathoracic lymphadenopathy and are of secondary character. The isolated affection of a pulmonary tissue without intrathoracic lymphadenopathy, as a rule, is detected at non-Hodgkin lymphomas.
Primary lymphomas of lungs are registered rarely. The majority of similar tumors now are related to B-cellular non-Hodgkin lymphomas. They are primary extranodal lymphomas of low malignancy and are called MALT-lymphomas. MALT-lymphomas are up to 70 % of all primary lymphomas of lungs.

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Bioplasm 9d nls analyzer plays a big role

The main advantages of nonlinear diagnostics for a doctor in sports medicine are:
1. Quickness of a complex evaluation of a sportsman health condition.
2. Visualization of muscles tone disbalance.
3. Highly accurate objectification of pre-clinical conditions of organs and systems, the latent “emotional”, “chemical”, “structural” and “energy” limiting factors.
4. Possibility of identifying the true reasons of a pathological process and a muscular disbalance.
5. Operative control over dynamics of a functional condition of a sportsman and applied treatment in any conditions of training and competitive processes.
6. Documentary justification of treatment application to practically healthy sportsmen.
7. Preventive and prognostic targeting.
Integration of nonlinear diagnostics into sports medicine gives an opportunity to raise the knowledge and possibilities of team doctors of any sports in search of reserve potentials in sportsmen to a new level.

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Thus, nonlinear diagnostics, in any conditions and periods of competitive activity, allows to reveal limiting factors, to monitor dynamics of a functional condition of sportsmen in due time and objectify an individual approach to applied restorative actions.
Algorithm of restorative actions:
1. Local differentiated treatment of problem muscles with massage, ischemic compression of trigger knots or postisometric stretching, myofascial release, stretching with percussion and others;
2. Elimination of pathological reflexes originating from organs associated with hypotonic muscles, various functional blocks, compressions of peripheral nerves, venous and lymphatic stagnation, negative emotions, etc. We applied craniosacral, visceral techniques, correction of diaphragms, treatment of temporomandibular joint, manual and reflex therapy, correction of biochemical problems, pathogenic flora, diet, etc.
3. Restoration of optimum performance of muscle-fascial links by a method of motion pattern reduction and training with use of an unstable platform.
After application of restorative actions asymmetry of force exertion to pedals decreased considerably according to results of repeated cycle ergometry testing.

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bioplasm machine-diagnostics method allows to glance into a prepathology condition

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Actually, bioplasm machine-diagnostics method allows to “glance” into a prepathology condition of sportsmen and to reveal the latent reserves there. The main limiting factors of healthy bicyclists performance were functional abnormalities of biochemical processes: endogenous and exogenous intoxications, abnormalities of acid-alkali balance, albuminous, fatty and carbohydrate exchange, a deficiency or excess of certain substances. Excessive stress to reflectory weak muscles leads to formation of structural changes in them, and also in tendons, joints and bones. Fascial shortenings in antagonistic muscles are developed as a compensatory reaction to weakness of agonistic muscles. Emotional stress, specific character of riding a bicycle (restriction of upper limb girdle compensatory rotations, laboring belly breath, fixed foot) also violate a natural optimum pattern of a sportsman walking with formation of various compensatory sanogenic reactions.

Bioplasm nls system has registered different degree of abnormalities of muscles functional condition severity

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We followed the algorithm of kinesiologic diagnostics and revealed the following in these sportsmen: pachymeninx torsion signs, a spasm of phrenic diaphragm, cranial abnormalities, dysfunctions of temporomandibular joint and lower ribs, signs of nervus vagus and accessory nerve in jugular aperture compression, dysfunction of internal organs, dysfunction of proximal syndesmosis of shin and fibular bone heads, displacement of ankle bone and others.
At a following stage we searched the main reasons of the revealed muscular disbalance. In 75 % of sportsmen the main reason of associated muscles weakness were biochemical abnormalities, developing from affected organs. Along with kinesiologic diagnostics we applied method of nonlinear diagnostics in order to identify further search of limiting biochemical factors.

In all studied patients “bioplasm nls” system has registered different degree of abnormalities of muscles functional condition severity. In most cases stress of regulatory mechanisms was revealed in those muscles which kinesiologically were evaluated as weak.

Bioplasm results of the study

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RESULTS OF THE STUDY
We revealed signs of asymmetry and torsion of body regions of a different degree in statics in 100 % of bicyclists. Visual diagnostics of a dynamic stereotype revealed abnormalities of tone-strength balance of agonist and antagonist muscles of typical motor patterns and advancing inclusion of synergists, neutralizers and fixator muscles into motion. A chest type of breath prevailed over a belly type.
Palpatory diagnostics revealed morbidity of a shin and a hip muscles insertion sites, abdominal wall, iliac muscle, dorsal gluteal muscle and piriform muscle, scalariform, diamond-shaped, trapezius and bowing muscles.
Manual diagnostics revealed functional blocks in cervicothoracic and lumbosacral passages, torsion of a basin with relative shortening of lower extremity in 83% of sportsmen. In 3 racers true shortening of shin or hip bones from 6 to 10 mm was confirmed by X-ray.

In 20 main sportsmen cycle ergometry testing helped to study force exertion to pedals and a saddle. The difference in force was from 5% to 15%.

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Instrumental: cycle ergometry testing of force exertion symmetry to pedals and a saddle, nonlinear (NLS) diagnostics by means of the certificated portable hardware-diagnostic complex “bioplasm nls software manufactured by the Institute of Practical Psychophysics. Unlike the Voll’s electropuncture diagnostics method where the energy potentials of the organs and systems are measured via bioactive points, with non-linear diagnostics the evaluation of the organ’s condition is done immediately based on the resonant amplification of investigated organ’s emission and reading the parameters noncontactly by of using trigger sensors.
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There were several basic inducing reasons of this search:
1. Periodically carried out standard clinical and functional tests showed “normal condition” in the overwhelming majority of sportsmen. However clinical concept “healthy” within the limits of general norm is not a guarantee of stable performance of a sportsman. In the majority of these healthy bicyclists elements of non-optimum statics and difference in some muscles volume are visually detected. Thorough interview has revealed minimum periodic conditions of discomfort in digestive system, upper respiratory ways or a backbone, perceived by sportsmen as normal. Applied manual therapy not always has a long-lasting effect, therefore the disbalance of muscles returns.
2. Modern requirements to diagnostics of a functional condition of a sportsman are: promptness, informativity and reliability based on logically constructed system of simple and easily performed tests. De facto, diagnostic possibilities of the majority of team’s doctors in “field” conditions are limited by the thermometer, a tonometer, a phonendoscope and the portable electrocardiograph.
3. Trainers and sportsmen associate team’s doctor, first of all, with medicaments, but possibilities of urgent medicamentous restoration during races in Europe are limited with every year. At the moment provisions of the L’Union Cycliste Internationale (UCI) forbid any injections during competitions.
4. Completeness of applied pharmacological maintenance of sports activity is basically limited to personal empirical experience of a doctor. A method of vitamins, minerals and basic nutriceuticals deficiency detection in «field conditions», taking into consideration specific features of a sportsman, is vitally important.
5. A method of quantitative estimation of racer’s strength does not guarantee proper endurance during many-days race. More intense fatigue develops in those sportsmen with frequently recurrent muscle disbalance. A method of qualitative evaluation of a sportsman’s muscles condition is of high-demand.
6. Psycho-emotional stress of professional sportsmen is extremely high, but there is no diagnostic and correctional methods improving a resistance to such stresses, which can be used in “field” conditions.

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Thus, Bioplasm 9d nls-research with NLS-ultramicroscanning is a promising method of sports trauma diagnostics, allowing to reveal the damages of muscles which are not diagnosed by other methods; and also it can be used as a way of navigation for minimum invasive medical interventions.
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